Inflammatory regulation of stem-like cells in melanoma

Melanoma Res. 2017 Feb;27(1):1-7. doi: 10.1097/CMR.0000000000000303.

Abstract

The link between inflammation, immunity and cancer is well established. In the last decade, there has been considerable excitement over cancer stem cells, believed to be a subset of tumour cells responsible for their initiation, propagation and resistance to conventional chemoradiotherapy. In this review, we discuss the characterization of cancer stem cells and describe their modulation by inflammation with a focus on melanoma.

Publication types

  • Review

MeSH terms

  • ATP Binding Cassette Transporter, Subfamily B
  • ATP Binding Cassette Transporter, Subfamily B, Member 1 / metabolism
  • Drug Resistance, Neoplasm
  • Humans
  • Inflammation / metabolism*
  • Melanoma / drug therapy
  • Melanoma / immunology*
  • Melanoma / metabolism*
  • Microphthalmia-Associated Transcription Factor / metabolism
  • NF-kappa B / metabolism
  • Neoplastic Stem Cells / immunology*
  • Neoplastic Stem Cells / metabolism*
  • Nerve Tissue Proteins / metabolism
  • Phenotype
  • Phosphatidylinositol 3-Kinases / metabolism
  • Protein Kinase Inhibitors / therapeutic use
  • Proto-Oncogene Proteins B-raf / antagonists & inhibitors
  • Proto-Oncogene Proteins c-akt / metabolism
  • Receptors, Nerve Growth Factor / metabolism
  • Receptors, Notch / metabolism
  • Signal Transduction*
  • Tumor Escape
  • Tumor Microenvironment

Substances

  • ABCB5 protein, human
  • ATP Binding Cassette Transporter, Subfamily B
  • ATP Binding Cassette Transporter, Subfamily B, Member 1
  • Microphthalmia-Associated Transcription Factor
  • NF-kappa B
  • NGFR protein, human
  • Nerve Tissue Proteins
  • Protein Kinase Inhibitors
  • Receptors, Nerve Growth Factor
  • Receptors, Notch
  • Proto-Oncogene Proteins B-raf
  • Proto-Oncogene Proteins c-akt