A new sarasinoside congener, sarasinoside M2, from a marine sponge collected in the Solomon Islands

Abstract

A new sarasinoside congener (sarasinoside M₂) and known sarasinoside B₁ were obtained from a marine sponge. Sarasinoside M₂ was suggested to have the same aglycon as sarasinoside M although the internal glucose in its sugar moiety is replaced by xylose. Sarasinosides B₁ and M₂ showed moderate cytotoxicity (approximate IC₅₀ 5-18 μM) toward Neuro-2a and HepG2 cell lines.

Keywords: MS/MS; cytotoxicity; marine sponge; saponin; sarasinoside M2.