Synthesis of a Water-Soluble Carboxylatobiphen[4]arene and Its Selective Complexation toward Acetylcholine

Junwei Ma; Qingbin Meng; Xiaoshi Hu; Bin Li; Suxiang Ma; Bingwen Hu; Jian Li; Xueshun Jia; Chunju Li

doi:10.1021/acs.orglett.6b03005

Synthesis of a Water-Soluble Carboxylatobiphen[4]arene and Its Selective Complexation toward Acetylcholine

Org Lett. 2016 Nov 4;18(21):5740-5743. doi: 10.1021/acs.orglett.6b03005. Epub 2016 Oct 19.

Authors

Junwei Ma¹, Qingbin Meng², Xiaoshi Hu³, Bin Li^{1

2}, Suxiang Ma¹, Bingwen Hu³, Jian Li¹, Xueshun Jia^{1

4}, Chunju Li¹

Affiliations

¹ Department of Chemistry, Center for Supramolecular and Catalytic Chemistry, Shanghai University , Shanghai 200444, P. R. China.
² State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology , Beijing 100850, P. R. China.
³ School of Physics and Materials Science, Shanghai Key Laboratory of Magnetic Resonance, East China Normal University , Shanghai 200062, P. R. China.
⁴ State Key Laboratory of Applied Organic Chemistry, Lanzhou University , Lanzhou 730000, P. R. China.

PMID: 27759397
DOI: 10.1021/acs.orglett.6b03005

Abstract

The first water-soluble biphen[4]arene containing eight carboxylato moieties (carboxylatobiphen[4]arene, CBP4) has been synthesized. Selective molecular recognition of acetylcholine (ACh) against choline (Ch) and betaine (Bt) and pH-responsive host-guest complexation in aqueous media are described.

Publication types

Research Support, Non-U.S. Gov't