Paternity calculations in a di-spermy case

Bruce Budowle; Christina Capt; Ranajit Chakraborty; Jianye Ge

doi:10.1007/s00414-016-1463-8

Paternity calculations in a di-spermy case

Int J Legal Med. 2017 Mar;131(2):339-343. doi: 10.1007/s00414-016-1463-8. Epub 2016 Oct 18.

Authors

Bruce Budowle^{1

2}, Christina Capt³, Ranajit Chakraborty³, Jianye Ge⁴

Affiliations

¹ Institute of Applied Genetics, Center for Human Identification, University of North Texas Health Science Center, 3500 Camp Bowie Blvd., Fort Worth, TX, USA. bruce.budowle@unthsc.edu.
² Center of Excellence in Genomic Medicine Research (CEGMR), King Abdulaziz University, Jeddah, Saudi Arabia. bruce.budowle@unthsc.edu.
³ Institute of Applied Genetics, Center for Human Identification, University of North Texas Health Science Center, 3500 Camp Bowie Blvd., Fort Worth, TX, USA.
⁴ Human Identification, Thermo Fisher Scientific, South San Francisco, CA, USA.

PMID: 27757578
DOI: 10.1007/s00414-016-1463-8

Abstract

In a criminal paternity case, which involved analysis of the product of conception, a rare circumstance was observed. The product of conception was triploidy, apparently due to an egg fertilized by two sperm. Since there is little guidance on how to calculate the probability of the DNA evidence given some basic hypotheses, the formulae were derived and are presented herein. These approaches could provide guidance for similar situations if they arise.

Keywords: Partial molar pregnancy; Paternity index; Paternity test; Polyspermy; Product of conception; Triploid.

MeSH terms

Female
Gene Frequency
Genotype
Humans
Likelihood Functions
Male
Microsatellite Repeats
Models, Statistical*
Paternity*
Rape / statistics & numerical data
Triploidy*