Recovery from Toxic-Induced Demyelination Does Not Require the NG2 Proteoglycan

PLoS One. 2016 Oct 18;11(10):e0163841. doi: 10.1371/journal.pone.0163841. eCollection 2016.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antigens / genetics
  • Brain / drug effects
  • Brain / metabolism
  • Brain / ultrastructure
  • Cell Differentiation / genetics
  • Cell Movement / genetics
  • Cell Proliferation / drug effects
  • Cells, Cultured
  • Cuprizone
  • Demyelinating Diseases / chemically induced
  • Demyelinating Diseases / genetics
  • Demyelinating Diseases / metabolism*
  • Gene Expression
  • Immunohistochemistry
  • Mice, Knockout
  • Mice, Transgenic
  • Microscopy, Electron
  • Oligodendroglia / cytology
  • Oligodendroglia / metabolism*
  • Proteoglycans / deficiency*
  • Proteoglycans / genetics
  • Receptor, Platelet-Derived Growth Factor alpha / genetics
  • Receptor, Platelet-Derived Growth Factor alpha / metabolism
  • Reverse Transcriptase Polymerase Chain Reaction
  • Stem Cells / cytology
  • Stem Cells / metabolism*

Substances

  • Antigens
  • Proteoglycans
  • chondroitin sulfate proteoglycan 4
  • Cuprizone
  • Receptor, Platelet-Derived Growth Factor alpha

Grants and funding

This work was funded by German Research Foundation (SFB-TR128-B7, http://www.dfg.de/) to TK and JT; Interdisciplinary Clinical Research Center, Münster (KuT3/012/15, http://campus.uni-muenster.de/izkf-start/) to TK; Hertie Foundation (P1130073, http://www.ghst.de/) to TK. All funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.