Abstract
Synthesis and pharmacological properties of the 5-fluoro-nicotinic ester with isosorbide-5-mononitrate 3 are reported. The new compound shows an in vitro activity on rabbit aortic helical strips five times higher than isosorbide-5-mononitrate. The hypotensive activity in guinea-pigs of 3 is markedly superior to that of 5-ISMN. In the rat 3 shows a bioavailability and an acute toxicity inferior to those of 5-ISMN after oral administration.
MeSH terms
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Animals
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Antihypertensive Agents / chemical synthesis*
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Antihypertensive Agents / toxicity
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Blood Pressure / drug effects
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Chemical Phenomena
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Chemistry
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Female
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Guinea Pigs
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In Vitro Techniques
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Isosorbide Dinitrate / analogs & derivatives*
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Isosorbide Dinitrate / chemical synthesis
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Isosorbide Dinitrate / pharmacology
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Isosorbide Dinitrate / toxicity
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Male
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Mice
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Rabbits
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Rats
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Rats, Inbred Strains
Substances
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Antihypertensive Agents
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Isosorbide Dinitrate
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isosorbide-5-mononitrate