Abstract
Nine aminoalkylaminoanthraquinones (I-IX) were evaluated for their cytotoxic potency against normal and malignant mammalian cells. The 1.8-di-(aminopropylamino) derivative (VIII) exhibited significant activity against several tumor cell systems and had some selectivity. The toxicity of this compound was also tested in growing chick embryos.
MeSH terms
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Animals
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Anthraquinones / chemical synthesis
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Anthraquinones / pharmacology*
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Antineoplastic Agents* / chemical synthesis
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Cell Survival / drug effects
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Chick Embryo
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Fibroblasts / drug effects
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Glioma / pathology
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Leukemia P388 / pathology
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Neuroblastoma / pathology
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Tumor Cells, Cultured / drug effects*
Substances
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Anthraquinones
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Antineoplastic Agents