The effect of substituted aminoalkylaminoanthraquinones on eukaryotic cells

Drug Des Deliv. 1989 Jun;4(4):289-94.

Abstract

Nine aminoalkylaminoanthraquinones (I-IX) were evaluated for their cytotoxic potency against normal and malignant mammalian cells. The 1.8-di-(aminopropylamino) derivative (VIII) exhibited significant activity against several tumor cell systems and had some selectivity. The toxicity of this compound was also tested in growing chick embryos.

MeSH terms

  • Animals
  • Anthraquinones / chemical synthesis
  • Anthraquinones / pharmacology*
  • Antineoplastic Agents* / chemical synthesis
  • Cell Survival / drug effects
  • Chick Embryo
  • Fibroblasts / drug effects
  • Glioma / pathology
  • Leukemia P388 / pathology
  • Neuroblastoma / pathology
  • Tumor Cells, Cultured / drug effects*

Substances

  • Anthraquinones
  • Antineoplastic Agents