Non-human primate malaria parasites: out of the forest and into the laboratory

Parasitology. 2018 Jan;145(1):41-54. doi: 10.1017/S0031182016001335. Epub 2016 Oct 17.

Abstract

The study of malaria in the laboratory relies on either the in vitro culture of human parasites, or the use of non-human malaria parasites in laboratory animals. In this review, we address the use of non-human primate malaria parasite species (NHPMPs) in laboratory research. We describe the features of the most commonly used NHPMPs, review their contribution to our understanding of malaria to date, and discuss their potential contribution to future studies.

Keywords: Plasmodium cynomolgi; Plasmodium fieldi; Plasmodium gonderi; Plasmodium inui; Plasmodium knowlesi; Plasmodium simiovale; Plasmodium simium; malaria; monkey; primates.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Disease Models, Animal
  • Malaria / parasitology*
  • Malaria / transmission
  • Plasmodium / classification
  • Plasmodium / genetics
  • Plasmodium / physiology*
  • Primates*