Smooth Muscle Cell-Mimetic CO-Regulated Ion Nanochannels

Yanglei Xu; Xin Sui; Jiaqiao Jiang; Jin Zhai; Longcheng Gao

doi:10.1002/adma.201603478

Smooth Muscle Cell-Mimetic CO-Regulated Ion Nanochannels

Adv Mater. 2016 Dec;28(48):10780-10785. doi: 10.1002/adma.201603478. Epub 2016 Oct 17.

Authors

Yanglei Xu¹, Xin Sui¹, Jiaqiao Jiang¹, Jin Zhai¹, Longcheng Gao¹

Affiliation

¹ Key Laboratory of Bio-Inspired Smart Interfacial Science and Technology of Ministry of Education, Beijing Key Laboratory of Bio-Inspired Energy Materials and Devices, School of Chemistry and Environment, Beihang University, Beijing, 100191, P. R. China.

PMID: 27747946
DOI: 10.1002/adma.201603478

Abstract

A CO-regulated ion nanochannel is demonstrated, which is inspired by the living activity of CO-induced smooth muscle vasodilation. The mechanism relies on the fact that CO has a higher affinity with ferroporphyrin compared to carboxyl groups on the surface of the nanochannels. The cooperation effect of the released carboxyl groups and the conical asymmetric shape leads the ion transportation to be diode-like.

Keywords: K+ channels, ion nanochannels; carbon monoxide; ferroporphyrin; ion current rectification.