Cellular strategies to cope with protein aggregation

Essays Biochem. 2016 Oct 15;60(2):153-161. doi: 10.1042/EBC20160002.

Abstract

Nature has evolved several mechanisms to detoxify intracellular protein aggregates that arise upon proteotoxic challenges. These include the controlled deposition of misfolded proteins at distinct cellular sites, the protein disaggregation and refolding by molecular chaperones and/or degradation of misfolded and aggregated protein species by cellular clearance pathways. In this article, we discuss cellular the strategies of prokaroytes and eukaryotes to control protein aggregation.

Keywords: aggresome; amyloid; autophagy; chaperones; degradation; deposition; disaggregase; misfolding; polyQ; proteasome; protein quality control; proteostasis.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amyloid / metabolism
  • Animals
  • Cells / metabolism*
  • Humans
  • Molecular Chaperones / metabolism
  • Protein Aggregates
  • Protein Aggregation, Pathological / metabolism*
  • Protein Aggregation, Pathological / pathology
  • Protein Aggregation, Pathological / therapy

Substances

  • Amyloid
  • Molecular Chaperones
  • Protein Aggregates