Ziprasidone Augmentation in an Adolescent with Obsessive Compulsive Disorder: A Case Report

Sevcan Karakoç Demirkaya; Behiye Alyanak

Ziprasidone Augmentation in an Adolescent with Obsessive Compulsive Disorder: A Case Report

Psychopharmacol Bull. 2016 Mar 1;46(1):73-76.

Authors

Sevcan Karakoç Demirkaya¹, Behiye Alyanak¹

Affiliation

¹ Dr. Demirkaya, MD, Assistant Professor, Child and Adolescent Psychiatry, Adnan Menderes University Faculty of Medicine, Aydin, Turkey. Dr. Alyanak, MD, Professor, Child and Adolescent Psychiatry, Istanbul University Istanbul Faculty of Medicine, Istanbul, Turkey.

PMID: 27738375
PMCID: PMC5044488

Abstract

Obsessive compulsive disorder (OCD) is characterized by recurrent, unwanted thoughts (obsessions) and/or repetitive behaviors (compulsions). Although selective serotonin reuptake inhibitors are widely used to treat OCD, only half of the patients respond well. Several potentiation strategies including off-label use of antipsychotics (mostly risperidone, quetiapine) have been tried. Ziprasidone is an atypical antipsychotic with the best affinity ratio of 5 HT _2A/D2 and 5HT_2C/D2 receptors. There is a limited data on ziprasidone in pediatric groups. The case described in the following is an example for the augmentation with ziprasidone to treatment refractory OCD.

Keywords: augmentation; obsessive compulsive disorder; ziprasidone.