Draft Genome Sequence of Marine-Derived Bacillus subtilis TP-B0611, a Producer of Bacilosarcins and Amicoumacins

Hisayuki Komaki; Akira Hosoyama; Natsuko Ichikawa; Yasuhiro Igarashi

doi:10.1128/genomeA.01134-16

Draft Genome Sequence of Marine-Derived Bacillus subtilis TP-B0611, a Producer of Bacilosarcins and Amicoumacins

Genome Announc. 2016 Oct 13;4(5):e01134-16. doi: 10.1128/genomeA.01134-16.

Authors

Hisayuki Komaki¹, Akira Hosoyama², Natsuko Ichikawa², Yasuhiro Igarashi³

Affiliations

¹ Biological Resource Center, National Institute of Technology and Evaluation (NBRC), Chiba, Japan komaki-hisayuki@nite.go.jp.
² NBRC, Tokyo, Japan.
³ Biotechnology Research Center and Department of Biotechnology, Toyama Prefectural University, Toyama, Japan.

Abstract

Here, we report the draft genome sequence of Bacillus subtilis TP-B0611, which produces the isocoumarin-type compounds bacilosarcin and amicoumacin. The genome encodes three nonribosomal peptide synthetase (NRPS) gene clusters and one hybrid polyketide synthase (PKS)/NRPS gene cluster. The hybrid PKS/NRPS gene cluster was identified to be responsible for the biosynthesis of bacilosarcins and amicoumacins.