Novel evidence that the mannan-binding lectin pathway of complement activation plays a pivotal role in triggering mobilization of hematopoietic stem/progenitor cells by activation of both the complement and coagulation cascades

Leukemia. 2017 Jan;31(1):262-265. doi: 10.1038/leu.2016.278. Epub 2016 Oct 13.

Authors

M Adamiak^{1

2}, A Abdelbaset-Ismail¹, M Suszynska¹, A Abdel-Latif³, J Ratajczak¹, M Z Ratajczak^{1

2}

Affiliations

¹ Stem Cell Institute at James Graham Brown Cancer Center, University of Louisville, Louisville, KY, USA.
² Department of Regenerative Medicine Warsaw Medical University, Warsaw, Poland.
³ Division of Cardiovascular Medicine, Gill Heart Institute, University of Kentucky, Lexington, KY, USA.

No abstract available

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Blood Coagulation / physiology*
Complement Activation / physiology*
Hematopoietic Stem Cell Mobilization*
Mannose-Binding Lectin / genetics
Mannose-Binding Lectin / metabolism*
Mannose-Binding Protein-Associated Serine Proteases / genetics
Mice, Knockout

Substances

Mannose-Binding Lectin
MASP-1 protein, mouse
Mannose-Binding Protein-Associated Serine Proteases

Grants and funding