Ru-Catalyzed Dehydrogenative C-O Bond Formation with Anilines and Phenols

Christophe Heitz; Alexander W Jones; Bünyamin S Oezkaya; Christina L Bub; Marie-Laure Louillat-Habermeyer; Victoria Wagner; Frederic W Patureau

doi:10.1002/chem.201604764

Ru-Catalyzed Dehydrogenative C-O Bond Formation with Anilines and Phenols

Chemistry. 2016 Dec 12;22(50):17980-17982. doi: 10.1002/chem.201604764. Epub 2016 Oct 28.

Authors

Christophe Heitz¹, Alexander W Jones¹, Bünyamin S Oezkaya¹, Christina L Bub¹, Marie-Laure Louillat-Habermeyer¹, Victoria Wagner¹, Frederic W Patureau¹

Affiliation

¹ FB Chemie, Technische Universität Kaiserslautern, Erwin-Schrödinger Str. 52, 67663, Kaiserslautern, Germany.

PMID: 27731915
DOI: 10.1002/chem.201604764

Abstract

The Ru catalyzed cross-dehydrogenative C-O bond formation between anilines and phenols is described and discussed. The exclusive C-O versus C-N bond-formation selectivity, moreover in the absence of chelating-assisting directing groups and while leaving the N-H position untouched, is a remarkable feature of this metal-catalyzed radical cross-dehydrogenative coupling.

Keywords: C−H activation; C−O bond formation; aniline; cross-dehydrogenative couplings; ruthenium.