Polymer-based monolithic column with incorporated chiral metal-organic framework for enantioseparation of methyl phenyl sulfoxide using nano-liquid chromatography

Xin Wang; Alexandros Lamprou; Frantisek Svec; Yu Bai; Huwei Liu

doi:10.1002/jssc.201600810

Polymer-based monolithic column with incorporated chiral metal-organic framework for enantioseparation of methyl phenyl sulfoxide using nano-liquid chromatography

J Sep Sci. 2016 Dec;39(23):4544-4548. doi: 10.1002/jssc.201600810. Epub 2016 Nov 18.

Authors

Xin Wang^{1

2}, Alexandros Lamprou², Frantisek Svec², Yu Bai¹, Huwei Liu¹

Affiliations

¹ Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, Institute of Analytical Chemistry, College of Chemistry and Molecular Engineering, Peking University, Beijing, P. R. China.
² The Molecular Foundry, E. O. Lawrence Berkeley National Laboratory, Berkeley, CA, USA.

PMID: 27730732
DOI: 10.1002/jssc.201600810

Abstract

A new approach to the preparation of enantioselective porous polymer monolithic columns with incorporated chiral metal-organic framework for nano-liquid chromatography has been developed. While no enantioseparation was achieved with monolithic poly(4-vinylpyridine-co-ethylene dimethacrylate) column, excellent separations of both enantiomers of (±)-methyl phenyl sulfoxide were achieved with its counterpart prepared after admixing metal-organic framework [Zn₂ (benzene dicarboxylate)(l-lactic acid)(dmf)], which is synthesized from zinc nitrate, l-lactic acid, and benzene dicarboxylic acid in the polymerization mixture. These novel monolithic columns combined selectivity of the chiral framework with the excellent hydrodynamic properties of polymer monoliths, may provide a great impact on future studies in the field of chiral analysis by liquid chromatography.

Keywords: Chiral stationary phases; Enantioselectivity; Metal-organic frameworks; Nano-liquid chromatography; Polymer monoliths.