Development: For cloche the Bell Tolls

Marlies P Rossmann; Yi Zhou; Leonard I Zon

doi:10.1016/j.cub.2016.08.009

Development: For cloche the Bell Tolls

Curr Biol. 2016 Oct 10;26(19):R890-R892. doi: 10.1016/j.cub.2016.08.009. Epub 2016 Oct 10.

Authors

Marlies P Rossmann¹, Yi Zhou¹, Leonard I Zon²

Affiliations

¹ Stem Cell Program and Division of Hematology/Oncology, Children's Hospital Boston, Howard Hughes Medical Institute and Harvard Medical School, Boston, MA 02115, USA. Department of Medical Oncology and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA; Department of Stem Cell and Regenerative Biology and Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA.
² Stem Cell Program and Division of Hematology/Oncology, Children's Hospital Boston, Howard Hughes Medical Institute and Harvard Medical School, Boston, MA 02115, USA. Department of Medical Oncology and Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA; Department of Stem Cell and Regenerative Biology and Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA. Electronic address: zon@enders.tch.harvard.edu.

Abstract

A recent publication identifies npas4l as the gene defective in the well-known cloche mutant that lacks most endothelial as well as hematopoietic cells. This work poses intriguing questions as to the genetic and molecular nature of the origin of hemato-vascular lineages during early embryogenesis.

Publication types

Comment

MeSH terms

Animals
Humans
Mutation
Zebrafish Proteins / genetics*
Zebrafish*

Substances

Zebrafish Proteins

Abstract

Publication types

MeSH terms

Substances

Grants and funding