H3K36 methylation state and associated silencing mechanisms

Transcription. 2017 Jan;8(1):26-31. doi: 10.1080/21541264.2016.1246076. Epub 2016 Oct 10.

Abstract

Epigenetic marks determine cell fate via numerous reader proteins. H3K36 methylation is a common epigenetic mark that is thought to be associated with the activities of the RNA polymerase 2 C-terminal domain. We discuss a novel silencing mechanism regulated by Set2-dependent H3K36 methylation that involves exosome-dependent RNA processing.

Keywords: H3K36me; HDAC; Set2; epigenetics; exosome; heterochromatin.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Epigenesis, Genetic
  • Exons
  • Gene Silencing*
  • Histone-Lysine N-Methyltransferase / metabolism*
  • Histones / chemistry
  • Histones / metabolism*
  • Humans
  • Lysine / chemistry
  • Male
  • Methylation
  • Protein Domains
  • RNA Polymerase II / chemistry
  • RNA Polymerase II / metabolism*

Substances

  • Histones
  • Histone-Lysine N-Methyltransferase
  • RNA Polymerase II
  • Lysine