Despite the fact that HIV infection can still not be eradicated from carriers, tremendous advances in antiretroviral therapy have led to achieving sustained suppression of HIV replication in most treated individuals. This translates into huge benefits for both patients and their sexual partners. This message was emphasized during the last IAS Conference, held in Durban, South Africa, at the end of July 2016. In parallel with this major AIDS event, two major publications were released: the updated recommendations on HIV therapy and the PARTNER study.