Dose-response studies on the spermatogonial stem cells of the rhesus monkey (Macaca mulatta) after X irradiation

M M van Alphen; H J van de Kant; J A Davids; C J Warmer; A L Bootsma; D G de Rooij

Dose-response studies on the spermatogonial stem cells of the rhesus monkey (Macaca mulatta) after X irradiation

Radiat Res. 1989 Sep;119(3):443-51.

Authors

M M van Alphen¹, H J van de Kant, J A Davids, C J Warmer, A L Bootsma, D G de Rooij

Affiliation

¹ Department of Cell Biology, State University of Utrecht, Medical School, The Netherlands.

PMID: 2772137

Abstract

Studies of the dose response of the spermatogonial stem cells in the rhesus monkey were performed at intervals of 130 and 160 days after graded doses of X irradiation. The D0 of the spermatogonial stem cells was established using the total numbers of the type A spermatogonia that were present at 130 and 160 days after irradiation and was found to be 1.07 Gy; the 95% confidence interval was 0.90-1.34 Gy.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Dose-Response Relationship, Radiation
Macaca mulatta
Male
Radiation Tolerance
Spermatogonia / radiation effects*
Spermatozoa / radiation effects*
Stem Cells / radiation effects*