Neuronal SOCE: Myth or Reality?

Abstract

Store-operated Ca²⁺ entry (SOCE) is the primary Ca²⁺ influx pathway in non-excitable cells. Long thought to be absent in nerve cells, neuronal SOCE is gaining popularity. We argue here that the evidence for SOCE in neurons remains contentious, mostly because SOCE imaging assays are inadequate in these cells.

Keywords: SOCE; STIM; calcium imaging; endoplasmic reticulum; neuron.