Clinical characteristics and treatment outcomes of pulmonary disease caused by Mycobacterium chimaera

Seong Mi Moon; Su-Young Kim; Byung Woo Jhun; Hyun Lee; Hye Yun Park; Kyeongman Jeon; Hee Jae Huh; Chang-Seok Ki; Nam Yong Lee; Sung Jae Shin; Won-Jung Koh

doi:10.1016/j.diagmicrobio.2016.09.016

Clinical characteristics and treatment outcomes of pulmonary disease caused by Mycobacterium chimaera

Diagn Microbiol Infect Dis. 2016 Dec;86(4):382-384. doi: 10.1016/j.diagmicrobio.2016.09.016. Epub 2016 Sep 24.

Authors

Affiliations

¹ Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.
² Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.
³ Department of Microbiology, Yonsei University College of Medicine, Seoul, South Korea.
⁴ Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea. Electronic address: wjkoh@skku.edu.

PMID: 27720208
DOI: 10.1016/j.diagmicrobio.2016.09.016

Abstract

Mycobacterium chimaera is a recently described species distinct from M. intracellulare. M. chimaera is regarded as less virulent than M. intracellulare. Using multi-locus sequence-based identification, M. chimaera lung disease was diagnosed in 11 patients. Clinical characteristics and outcomes of M. chimaera lung disease were comparable to M. intracellulare lung disease.

Keywords: Mycobacterium avium complex; Mycobacterium chimaera; Mycobacterium intracellulare; Nontuberculous mycobacteria.

MeSH terms

Adult
Aged
Female
Humans
Male
Middle Aged
Multilocus Sequence Typing
Mycobacterium / classification*
Mycobacterium / genetics
Mycobacterium / isolation & purification*
Mycobacterium Infections, Nontuberculous / diagnosis*
Mycobacterium Infections, Nontuberculous / drug therapy*
Mycobacterium Infections, Nontuberculous / microbiology
Mycobacterium Infections, Nontuberculous / pathology
Pneumonia, Bacterial / diagnosis*
Pneumonia, Bacterial / drug therapy*
Pneumonia, Bacterial / microbiology
Pneumonia, Bacterial / pathology
Treatment Outcome