Kinetics of docosahexaenoic acid ethyl ester accumulation in dog plasma and brain

Prostaglandins Leukot Essent Fatty Acids. 2016 Oct:113:1-8. doi: 10.1016/j.plefa.2016.08.001. Epub 2016 Aug 16.

Abstract

This study explores dog plasma and brain fatty acid composition achieved after long-term supplementation at high DHA doses. A 90% concentrate of DHA Ethyl Ester (DHA-EE) administered by oral gavage to Beagle dogs at doses of 100, 500, 1000, and 2000mg/kg bw/day for 8 weeks resulted in DHA increases in both plasma and brain. In a subsequent 9-month study, DHA-EE was administered at 150, 1000 and 2000mg/kg bw/day. Plasma DHA increased between 150 and 1000mg/kg bw/day but not between 1000 and 2000mg/kg bw/day and there were increases from Day 1to 92 but not between days 92 and 273. Doses >500mg/kg bw/day in the 8-week and all doses in the 9-month study resulted in DHA increases in the brain. The dose of 150mg/k gbw/day is sufficient to achieve maximal brain concentrations if DHA is administered chronically. For shorter than 6 months of supplementation, higher doses are required.

Keywords: Algal oil; Brain; DHA ethyl ester; Docosahexaenoic acid; Dogs; Kinetics; Plasma.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Oral
  • Animals
  • Brain Chemistry*
  • Docosahexaenoic Acids / administration & dosage
  • Docosahexaenoic Acids / analysis*
  • Dogs
  • Dose-Response Relationship, Drug
  • Drug Administration Schedule
  • Female
  • Male
  • Plasma / chemistry*

Substances

  • Docosahexaenoic Acids
  • 4,7,10,13,16,19-docosahexaenoic acid ethyl ester