Healthcare-associated Gram-negative bloodstream infections: antibiotic resistance and predictors of mortality

J Hosp Infect. 2016 Dec;94(4):381-385. doi: 10.1016/j.jhin.2016.08.012. Epub 2016 Aug 21.

Abstract

This article describes the prevalence of antibiotic resistance and predictors of mortality for healthcare-associated (HA) Gram-negative bloodstream infections (GN-BSI). In total, 831 cases of HA GN-BSI from 17 intensive care units in different centres in Turkey were included; the all-cause mortality rate was 44%. Carbapenem resistance in Klebsiella pneumoniae was 38%, and the colistin resistance rate was 6%. Multi-variate analysis showed that age >70 years [odds ratio (OR) 2, 95% confidence interval (CI) 1.22-3.51], central venous catheter use (OR 2.1, 95% CI 1.09-4.07), ventilator-associated pneumonia (OR 1.9, 95% CI 1.1-3.16), carbapenem resistance (OR 1.8, 95% CI 1.11-2.95) and APACHE II score (OR 1.1, 95% CI 1.07-1.13) were significantly associated with mortality.

Keywords: Bloodstream; Gram-negative; Healthcare.

Publication types

  • Multicenter Study

MeSH terms

  • Adult
  • Aged
  • Bacteremia / epidemiology
  • Bacteremia / microbiology
  • Bacteremia / mortality*
  • Cross Infection / epidemiology
  • Cross Infection / microbiology
  • Cross Infection / mortality*
  • Drug Resistance, Bacterial*
  • Female
  • Gram-Negative Bacteria / classification
  • Gram-Negative Bacteria / drug effects*
  • Gram-Negative Bacteria / isolation & purification*
  • Gram-Negative Bacterial Infections / epidemiology
  • Gram-Negative Bacterial Infections / microbiology
  • Gram-Negative Bacterial Infections / mortality*
  • Humans
  • Intensive Care Units
  • Male
  • Middle Aged
  • Prevalence
  • Prognosis
  • Retrospective Studies
  • Risk Factors
  • Survival Analysis
  • Turkey / epidemiology