Digit Tip Regeneration and Beyond: Schwann Cell Progenitors to the Rescue

Jessica A Lehoczky

doi:10.1016/j.stem.2016.09.006

Digit Tip Regeneration and Beyond: Schwann Cell Progenitors to the Rescue

Cell Stem Cell. 2016 Oct 6;19(4):417-418. doi: 10.1016/j.stem.2016.09.006.

Author

Jessica A Lehoczky¹

Affiliation

¹ Department of Orthopedic Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. Electronic address: jlehoczky@partners.org.

PMID: 27716518
DOI: 10.1016/j.stem.2016.09.006

Abstract

Digit tip regeneration following amputation is an innate response in some mammals, including mice. In this issue of Cell Stem Cell, Johnston et al. (2016) show that Schwann cell precursors are necessary for this process and can rescue regeneration in denervated digit tips through secretion of pro-regenerative factors including OSM and PDGF-AA.

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MeSH terms

Animals
Extremities
Mammals
Mice
Regeneration*
Schwann Cells
Stem Cells*