Overcoming Autofluorescence: Long-Lifetime Infrared Nanoparticles for Time-Gated In Vivo Imaging

Blanca Del Rosal; Dirk H Ortgies; Nuria Fernández; Francisco Sanz-Rodríguez; Daniel Jaque; Emma Martín Rodríguez

doi:10.1002/adma.201603583

Overcoming Autofluorescence: Long-Lifetime Infrared Nanoparticles for Time-Gated In Vivo Imaging

Adv Mater. 2016 Dec;28(46):10188-10193. doi: 10.1002/adma.201603583. Epub 2016 Oct 6.

Authors

Blanca Del Rosal¹, Dirk H Ortgies^{1

2}, Nuria Fernández¹, Francisco Sanz-Rodríguez^{1

2}, Daniel Jaque^{1

2}, Emma Martín Rodríguez^{1

2}

Affiliations

¹ Fluorescence Imaging Group, Departamento de Física de Materiales, Facultad de Ciencias, Universidad Autónoma de Madrid, Madrid, 28049, Spain.
² Instituto Ramón y Cajal de Investigación Sanitaria, IRYCIS, Ctra. Colmenar km. 9.100, Madrid, 28034, Spain.

PMID: 27711997
DOI: 10.1002/adma.201603583

Abstract

The always present and undesired contribution of autofluorescence is here completely avoided by combining a simple time gating technology with long lifetime neodymium doped infrared-emitting nanoparticles.

Keywords: autofluorescence; bioimaging; infrared imaging; rare earth nanoparticles.

MeSH terms

Animals
Fluorescence*
Infrared Rays*
Mice
Nanoparticles / chemistry*
Neodymium / chemistry*
Optical Imaging / methods*
Time Factors

Substances

Neodymium