Anti-inflammatory activity and enhanced COX-2 selectivity of nitric oxide-donating zinc(ii)-NSAID complexes

Dalton Trans. 2016 Sep 13;45(36):14053-14057. doi: 10.1039/c6dt00838k.

Abstract

Zinc(ii)-NSAID complexes supported by NO-donating 1,10-phenanthrolinefuroxan exhibit anti-inflammatory activities through selective inhibition of the COX-2 pathway. The strategy represents a general procedure to convert non-selective or COX-1 selective NSAIDs to selective COX-2 inhibitors.

MeSH terms

  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal / chemistry
  • Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
  • Cyclooxygenase 1 / metabolism
  • Cyclooxygenase 2 / metabolism*
  • Dinoprostone / antagonists & inhibitors
  • Interferon-gamma / pharmacology
  • Ligands
  • Lipopolysaccharides / pharmacology
  • Mice
  • Nitric Oxide Donors / chemistry
  • Nitric Oxide Donors / pharmacology*
  • Oxadiazoles / chemistry
  • Oxadiazoles / pharmacology*
  • RAW 264.7 Cells
  • Zinc / chemistry
  • Zinc / pharmacology*

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Ligands
  • Lipopolysaccharides
  • Nitric Oxide Donors
  • Oxadiazoles
  • Interferon-gamma
  • Cyclooxygenase 1
  • Cyclooxygenase 2
  • Zinc
  • Dinoprostone