Abstract
Zinc(ii)-NSAID complexes supported by NO-donating 1,10-phenanthrolinefuroxan exhibit anti-inflammatory activities through selective inhibition of the COX-2 pathway. The strategy represents a general procedure to convert non-selective or COX-1 selective NSAIDs to selective COX-2 inhibitors.
MeSH terms
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Animals
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Anti-Inflammatory Agents, Non-Steroidal / chemistry
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Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
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Cyclooxygenase 1 / metabolism
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Cyclooxygenase 2 / metabolism*
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Dinoprostone / antagonists & inhibitors
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Interferon-gamma / pharmacology
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Ligands
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Lipopolysaccharides / pharmacology
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Mice
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Nitric Oxide Donors / chemistry
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Nitric Oxide Donors / pharmacology*
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Oxadiazoles / chemistry
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Oxadiazoles / pharmacology*
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RAW 264.7 Cells
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Zinc / chemistry
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Zinc / pharmacology*
Substances
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Anti-Inflammatory Agents, Non-Steroidal
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Ligands
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Lipopolysaccharides
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Nitric Oxide Donors
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Oxadiazoles
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Interferon-gamma
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Cyclooxygenase 1
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Cyclooxygenase 2
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Zinc
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Dinoprostone