A conformation and charge co-modulated ultrasensitive biomimetic ion channel

Sheng-Lin Cai; Yu-Bin Zheng; Shuo-Hui Cao; Xiu-Hong Cai; Yao-Qun Li

doi:10.1039/c6cc04899d

A conformation and charge co-modulated ultrasensitive biomimetic ion channel

Chem Commun (Camb). 2016 Oct 13;52(84):12450-12453. doi: 10.1039/c6cc04899d.

Authors

Sheng-Lin Cai¹, Yu-Bin Zheng¹, Shuo-Hui Cao², Xiu-Hong Cai¹, Yao-Qun Li¹

Affiliations

¹ Department of Chemistry and Key Laboratory of Analytical Sciences, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, 361005, P. R. China. yaoqunli@xmu.edu.cn.
² Department of Chemistry and Key Laboratory of Analytical Sciences, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, 361005, P. R. China. yaoqunli@xmu.edu.cn and Department of Electronic Science, Xiamen University, Xiamen, 361005, P. R. China.

PMID: 27709163
DOI: 10.1039/c6cc04899d

Abstract

For the first time, a biomimetic ion channel co-modulated simultaneously by conformation and charge using a single stimulus has been demonstrated, and, based on the synergetic effect of this channel, an ultrasensitive nanopore sensor for ATP with a limit of detection down to sub-pM was developed.