Recent progress on the discovery of antiamoebic agents

Faisal Hayat; Amir Azam; Dongyun Shin

doi:10.1016/j.bmcl.2016.09.040

Recent progress on the discovery of antiamoebic agents

Bioorg Med Chem Lett. 2016 Nov 1;26(21):5149-5159. doi: 10.1016/j.bmcl.2016.09.040. Epub 2016 Sep 15.

Authors

Faisal Hayat¹, Amir Azam², Dongyun Shin³

Affiliations

¹ College of Pharmacy, Gachon University, 191 Hambakmoe-ro, Yeonsu-gu, Incheon 21936, South Korea.
² Department of Chemistry, Jamia Millia Islamia (Central University), Jamia Nagar, New Delhi 110025, India.
³ College of Pharmacy, Gachon University, 191 Hambakmoe-ro, Yeonsu-gu, Incheon 21936, South Korea. Electronic address: dyshin@gachon.ac.kr.

PMID: 27707603
DOI: 10.1016/j.bmcl.2016.09.040

Abstract

A large number of protozoans infect humans but Entamoeba histolytica is the only organism responsible for causing amoebiasis, a deadly disease after malaria. Numerous heterocycle-based antiamoebic agents have been previously synthesized as E. histolytica inhibitors and while some of these agents have shown moderate activity, the search for a novel and ideal antiamoebic compound is still ongoing. In this digest Letter, we present the latest data on antiamoebic agents from 2011 to 2016 based on the different classes of heterocyclic agents.

Keywords: Amoebiasis; Antiamoebic; Entamoeba histolytica; Inhibitor; Protozoan.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antiprotozoal Agents / pharmacology*
Cell Line
Drug Discovery
Entamoeba histolytica / drug effects*
Heterocyclic Compounds / pharmacology
Humans
Inhibitory Concentration 50

Substances

Antiprotozoal Agents
Heterocyclic Compounds