2-(2-Phenylethyl)chromone Derivatives of Agarwood Originating from Gyrinops salicifolia

Molecules. 2016 Oct 3;21(10):1313. doi: 10.3390/molecules21101313.

Abstract

Three new2-(2-phenylethyl)chromone derivatives (1-3) and a new2-(2-phenylethenyl)chromone derivative (4), together with two known 2-(2-phenylethyl)chromone derivatives (5-6), were isolated from agarwood originating from Gyrinops salicifolia Ridl. The structures of compounds 1-4 were elucidated by comprehensive spectroscopic techniques (UV, IR, 1D and 2D-NMR) and MS analysis, as well as by comparison with the literature. Compounds 1, 2, and 5 showed moderate cytotoxicity against human tumor K562, BEL-7402, and SGC-7901 cell lines with IC50 values of 5.76 to 20.1 µM.

Keywords: 2-(2-phenylethenyl)chromone derivative; 2-(2-phenylethyl)chromone derivative; Gyrinops salicifolia; agarwood; cytotoxicity.

MeSH terms

  • Antineoplastic Agents / chemistry*
  • Antineoplastic Agents / pharmacology
  • Cell Line, Tumor
  • Chromones / chemistry*
  • Chromones / isolation & purification
  • Chromones / pharmacology
  • Flavonoids / chemistry*
  • Flavonoids / pharmacology
  • Humans
  • K562 Cells
  • Magnoliopsida / chemistry*
  • Molecular Structure
  • Plant Extracts / chemistry*

Substances

  • Antineoplastic Agents
  • Chromones
  • Flavonoids
  • Plant Extracts
  • 2-(2-phenylethyl)chromone