Ligand-Driven T Cell Receptor Selection in Celiac Disease

Nishant K Singh; Brian M Baker

doi:10.1016/j.str.2016.09.004

Ligand-Driven T Cell Receptor Selection in Celiac Disease

Structure. 2016 Oct 4;24(10):1623-1624. doi: 10.1016/j.str.2016.09.004.

Authors

Nishant K Singh¹, Brian M Baker²

Affiliations

¹ Department of Chemistry & Biochemistry and the Harper Cancer Research Institute, University of Notre Dame, 251 Nieuwland Science Hall, Notre Dame, IN 46556, USA. Electronic address: nishant.k.singh.32@nd.edu.
² Department of Chemistry & Biochemistry and the Harper Cancer Research Institute, University of Notre Dame, 251 Nieuwland Science Hall, Notre Dame, IN 46556, USA. Electronic address: brian-baker@nd.edu.

PMID: 27705812
DOI: 10.1016/j.str.2016.09.004

Abstract

Recognition of antigens by T cell receptors (TCRs) underlies cellular immunity. By comparing how different TCRs recognize the key antigens associated with celiac disease, Petersen et al. (2016), in this issue of Structure, show how celiac antigen properties select immunologically distinct yet structurally and physically compatible TCRs, ultimately driving autoimmunity.

Publication types

Comment

MeSH terms

Celiac Disease*
Humans
Ligands
Lymphocyte Activation
Receptors, Antigen, T-Cell / chemistry*

Substances

Ligands
Receptors, Antigen, T-Cell

Grants and funding

R35 GM118166/GM/NIGMS NIH HHS/United States