Background and objectives: Seventy six hemodialysis (HD) patients were used in a prospective randomized and clinical trial to determine if a multivitamin with vitamin D (cholecalciferol 12,000 IU/week) given during dialysis would improve the vitamin D status of hemodialysis subjects.
Methods and study design: Subjects were randomly assigned to two groups: 37 subjects were in the renal multivitamin without vitamin D (MV) group and 39 subjects were in a multivitamin route with vitamin D (MVD) group (12,000 IU of cholecalciferol per week). All subjects were given 2 multivitamin tablets at their 3 HD sessions each week for 20 weeks. Serum 25(OH)D, calcium (Ca), and phosphorus (P) levels were evaluated.
Results: At baseline, mean serum 25(OH)D were below adequate (<30 ng/mL) in the MV group (23.5±12.2 ng/mL) and in the MVD group (20.8±10.3 ng/mL). A significant increase was seen in serum 25(OH)D levels (37.7±11.4 ng/mL; p<0.001) in the MVD group after vitamin D supplementation with no rise in the MV group value (21.7±11.4 ng/mL; p=0.06). Prior to supplementation, 17.9% of patients in the MVD group had adequate serum 25(OH)D level and post supplementation 76.9% in the MVD group had adequate serum 25(OH)D. In the MV group, 18.9% subjects had adequate serum 25(OH)D levels at baseline with 18.9% having 25(OH)D >30 ng/mL at the end of the study. There were no significant differences in group values for serum Ca and P.
Conclusion: The majority of HD subjects given a multivitamin with cholecalciferol at dialysis had improvement in their vitamin D status.
背景与目的：为确定在透析时给予含维生素D（胆钙化醇12,000 IU/周）的复 合维生素是否能够改善血液透析患者的维生素D 状态，进行该项包括76 位血 液透析（HD）患者的前瞻性随机临床试验。方法与研究设计：受试者被随机分 为两组：37 位分在不含维生素D 的复合维生素组（MV），另外39 位分在含维 生素D 的复合维生素组（MVD，胆钙化醇12,000 IU/周）。所有受试者在HD 第3 阶段每周给予2 片复合维生素，持续20 周。评估其血清25(OH)D、钙和磷 浓度。结果：两组患者基线平均血清25(OH)D 均不足（<30 ng/mL），MV 组 为23.5±12.2 ng/mL，MVD 组为20.8±10.3 ng/mL。补充维生素D 之后，MVD 组血清25(OH)D 浓度显著升高37.7±11.4 ng/mL；p<0.001，而MV 组血清 25(OH)D 浓度没有升高（21.7±11.4 ng/mL；p=0.06）。补充前，MVD 组有 17.9%的患者血清25(OH)D 充足，补充后，MVD 组有76.9%的患者血清 25(OH)D 充足。在MV 组，基线时有18.9%的患者血清25(OH)D 充足，试验结 束时，血清25(OH)D>30 ng/mL 的患者仍然只占18.9%。两组血清钙和磷在补 充前后没有显著变化。结论：大多数HD 患者在透析时给予含胆钙化醇的复合 维生素可以改善他们的维生素D 状态。.