Variation of HPV Subtypes with Focus on HPV-Infection and Cancer in the Head and Neck Region

Gunnar Wichmann

doi:10.1007/978-3-319-43580-0_8

Variation of HPV Subtypes with Focus on HPV-Infection and Cancer in the Head and Neck Region

Recent Results Cancer Res. 2017:206:113-122. doi: 10.1007/978-3-319-43580-0_8.

Author

Gunnar Wichmann¹

Affiliation

¹ ENT-Research Laboratory, Clinic of Otolaryngology, Head and Neck Surgery and Department of Head Medicine and Oral Health, University of Leipzig, Liebigstr. 21, 04103, Leipzig, Germany. gunnar.wichmann@medizin.uni-leipzig.de.

PMID: 27699533
DOI: 10.1007/978-3-319-43580-0_8

Abstract

The human papillomavirus (HPV) comprises a heterogeneous group of double-strand DNA viruses with variable potential to infect human epithelial cells and trigger neoplastic transformation. Its 8 kb genome encodes proteins required for virus replication and self-organized formation of infectious particles but also for early proteins E6 and E7 able to trigger neoplastic transformation. E6 and E7 of high-risk (HR) HPV subtypes can bind to p53 or release E2F and abrogate replication control. Due to variable amino acid sequence (AAS) in the binding sites of E6 and E7 particular HR-HPV variants within subtypes are essentially heterogeneous in efficacy triggering neoplastic transformation and cancer development. This could explain differences in the clinical course of HPV-driven head and neck cancer.

Keywords: HPV subtypes; HPV variants; HPV16 AA; HPV16 E6 variants; Head and neck squamous cell carcinoma (HNSCC); Human papilloma virus (HPV).

Publication types

Review

MeSH terms

Carcinoma, Squamous Cell / virology*
Head and Neck Neoplasms / virology*
Humans
Oncogene Proteins, Viral / genetics
Papillomaviridae / genetics*
Papillomavirus Infections / virology*

Substances

Oncogene Proteins, Viral