Dataset of TWIST1-regulated genes in the cranial mesoderm and a transcriptome comparison of cranial mesoderm and cranial neural crest

Heidi Bildsoe; Xiaochen Fan; Emilie E Wilkie; Ator Ashoti; Vanessa J Jones; Melinda Power; Jing Qin; Junwen Wang; Patrick P L Tam; David A F Loebel

doi:10.1016/j.dib.2016.09.001

Dataset of TWIST1-regulated genes in the cranial mesoderm and a transcriptome comparison of cranial mesoderm and cranial neural crest

Data Brief. 2016 Sep 12:9:372-375. doi: 10.1016/j.dib.2016.09.001. eCollection 2016 Dec.

Authors

Affiliations

¹ Embryology Unit, Children's Medical Research Institute, Sydney Medical School, University of Sydney, Westmead, NSW 2145, Australia.
² Bioinformatics Group, Children's Medical Research Institute, Sydney Medical School, University of Sydney, Westmead, NSW 2145, Australia.
³ Embryology Unit, Children's Medical Research Institute, Sydney Medical School, University of Sydney, Westmead, NSW 2145, Australia; Biomedical Sciences, Faculty of Mathematics and Natural Sciences, University of Groningen, The Netherlands.
⁴ Centre for Genomic Sciences, Department of Biochemistry, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong SAR, China.

Abstract

This article contains data related to the research article entitled "Transcriptional targets of TWIST1 in the cranial mesoderm regulate cell-matrix interactions and mesenchyme maintenance" by Bildsoe et al. (2016) [1]. The data presented here are derived from: (1) a microarray-based comparison of sorted cranial mesoderm (CM) and cranial neural crest (CNC) cells from E9.5 mouse embryos; (2) comparisons of transcription profiles of head tissues from mouse embryos with a CM-specific loss-of-function of Twist1 and control mouse embryos collected at E8.5 and E9.5; (3) ChIP-seq using a TWIST1-specific monoclonal antibody with chromatin extracts from TWIST1-expressing MDCK cells, a model for a TWIST1-dependent mesenchymal state.