Novel Multitarget Hybrid Compounds for the Treatment of Alzheimer's Disease

Abstract

Alzheimer's disease (AD) is the most prevalent among the aging diseases known as neurodegenerative disorders. Drug design programs over the last two decades were mainly based on the cholinergic, the amyloid or the tau hypothesis. However, none of the new drugs have a real impact on the outcome of the disease. The complex nature of AD has led to new approaches for drug development programs, the multitarget drug design hypothesis. Based on this hypothesis, the generation of multitarget hybrid compounds from previously known active molecules has been one of the most widely used to obtain new candidates for the future treatment of AD. Here, we summarize recent developments based on the hybridization hypothesis to obtain a potential clinical candidate for AD.

Keywords: Alzheimer's disease; Antioxidants; Drug design; Dual AChE Inhibitors; Emerging targets for AD; Hybrid compounds; Multitarget drugs; Nrf2-EpRE inducers..