Retraction: "Response to dual blockade of epidermal growth factor receptor (EGFR) and cyclooxygenase-2 in nonsmall cell lung cancer may be dependent on the EGFR mutational status of the tumor" by Gadgeel SM, Ali S, Philip PA, Ahmed F, Wozniak A, Sarkar FH. The above article, published in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement amongst the journal Editor in Chief, Fadlo R. Khuri; Wiley Periodicals, Inc.; and the American Cancer Society following an investigation by Wayne State University into the research activities of the second and last authors. The investigation found that masking and other manipulations altered the appearance of certain Western blots published in Figure 1A beyond "cosmetic" changes, and that these alterations changed the results. The investigation further found that there was masking in p-EGFR bands of the H3255 cells in Figure 5A, and found no evidence that the "data" published as non-expressed COX-2 and Akt in the H1650 cells in Figures 5A and 5B are anything other than plain gray boxes. The investigation committee concluded that this undermined the scientific basis of the publication, that no credible replacement data were available, and advised that the publication should be retracted.
Reference: Gadgeel, S. M., Ali, S., Philip, P. A., Ahmed, F., Wozniak, A. and Sarkar, F. H. (2007), Response to dual blockade of epidermal growth factor receptor (EGFR) and cycloxygenase-2 in nonsmall cell lung cancer may be dependent on the EGFR mutational status of the tumor. Cancer, 110: 2775-2784. doi: 10.1002/cncr.23100.
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