Simultaneous Maximum-Likelihood Reconstruction of Absorption Coefficient, Refractive Index and Dark-Field Scattering Coefficient in X-Ray Talbot-Lau Tomography

PLoS One. 2016 Oct 3;11(10):e0163016. doi: 10.1371/journal.pone.0163016. eCollection 2016.

Abstract

A maximum-likelihood reconstruction technique for X-ray Talbot-Lau tomography is presented. This technique allows the iterative simultaneous reconstruction of discrete distributions of absorption coefficient, refractive index and a dark-field scattering coefficient. This technique avoids prior phase retrieval in the tomographic projection images and thus in principle allows reconstruction from tomographic data with less than three phase steps per projection. A numerical phantom is defined which is used to evaluate convergence of the technique with regard to photon statistics and with regard to the number of projection angles and phase steps used. It is shown that the use of a random phase sampling pattern allows the reconstruction even for the extreme case of only one single phase step per projection. The technique is successfully applied to measured tomographic data of a mouse. In future, this reconstruction technique might also be used to implement enhanced imaging models for X-ray Talbot-Lau tomography. These enhancements might be suited to correct for example beam hardening and dispersion artifacts and improve overall image quality of X-ray Talbot-Lau tomography.

MeSH terms

  • Animals
  • Interferometry
  • Likelihood Functions
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Models, Theoretical
  • Phantoms, Imaging
  • Radiographic Image Enhancement / methods
  • Refractometry
  • Scattering, Radiation
  • Tomography, X-Ray Computed* / methods

Grants and funding

We acknowledge support by Deutsche Forschungsgemeinschaft and Friedrich-Alexander-Universität Erlangen-Nürnberg within the funding program Open Access Publishing. AR thanks IMPRS-PL for scholarship. GA thanks the German Research Council (DFG grant AN 257/20-1). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.