Evaluation of Prostate Cancer with 11C-Choline PET/CT for Treatment Planning, Response Assessment, and Prognosis

J Nucl Med. 2016 Oct;57(Suppl 3):49S-54S. doi: 10.2967/jnumed.115.170126.

Abstract

The aim of this review is to report on the value of 11C-choline PET imaging as a diagnostic procedure for metastasis-directed therapies. Furthermore, the role of 11C-choline PET/CT as a diagnostic tool for monitoring castration-resistant prostate cancer patients treated with systematic therapy is assessed. Finally, the role of 11C-choline PET/CT in the prediction of survival in both castration-resistant prostate cancer patients and hormone-naïve patients is investigated.

Keywords: 11C-choline PET/CT; PET-guided therapies; metastasis-directed therapies; salvage lymph node dissection; salvage radiotherapy.

Publication types

  • Review

MeSH terms

  • Choline / analogs & derivatives*
  • Evidence-Based Medicine
  • Humans
  • Image Enhancement / methods
  • Male
  • Neoplasm Recurrence, Local / diagnostic imaging*
  • Neoplasm Recurrence, Local / pathology
  • Neoplasm Recurrence, Local / prevention & control*
  • Neoplasm Staging
  • Outcome Assessment, Health Care / methods
  • Positron Emission Tomography Computed Tomography / methods*
  • Prostatic Neoplasms / diagnostic imaging*
  • Prostatic Neoplasms / pathology
  • Prostatic Neoplasms / therapy*
  • Radiopharmaceuticals

Substances

  • Radiopharmaceuticals
  • methyl carbon-11 choline
  • Choline