11C- or 18F-Choline PET/CT for Imaging Evaluation of Biochemical Recurrence of Prostate Cancer

J Nucl Med. 2016 Oct;57(Suppl 3):43S-48S. doi: 10.2967/jnumed.115.169755.

Abstract

Recurrence of prostate cancer is suspected when an increase in the prostate-specific antigen level is detected after radical treatment; the recurrence could be local relapse, distant relapse, or both. Differentiation between the two patterns of relapse is critical for choosing the proper treatment strategy. Choline PET/CT could be of help in discriminating patients with local, lymph node, and bone recurrences, thus having an impact on patient management.

Keywords: 11C-choline; 18F-choline; PET/CT; biochemical recurrence; prostate cancer.

Publication types

  • Review

MeSH terms

  • Choline / analogs & derivatives*
  • Diagnosis, Differential
  • Evidence-Based Medicine
  • Humans
  • Image Enhancement / methods
  • Male
  • Neoplasm Recurrence, Local / diagnostic imaging*
  • Neoplasm Recurrence, Local / pathology
  • Neoplasm Recurrence, Local / prevention & control
  • Outcome Assessment, Health Care / methods
  • Positron Emission Tomography Computed Tomography / methods*
  • Prostatic Neoplasms / diagnostic imaging*
  • Prostatic Neoplasms / pathology
  • Prostatic Neoplasms / therapy*
  • Radiopharmaceuticals
  • Treatment Outcome

Substances

  • Radiopharmaceuticals
  • fluoromethylcholine
  • methyl carbon-11 choline
  • Choline