Cell fate regulation by chromatin ADP-ribosylation

Jeannette Abplanalp; Michael O Hottiger

doi:10.1016/j.semcdb.2016.09.010

Cell fate regulation by chromatin ADP-ribosylation

Semin Cell Dev Biol. 2017 Mar:63:114-122. doi: 10.1016/j.semcdb.2016.09.010. Epub 2016 Sep 28.

Authors

Jeannette Abplanalp¹, Michael O Hottiger²

Affiliations

¹ Department of Molecular Mechanisms of Disease, University of Zurich, Winterthurerstr. 190, 8057 Zurich, Switzerland.
² Department of Molecular Mechanisms of Disease, University of Zurich, Winterthurerstr. 190, 8057 Zurich, Switzerland. Electronic address: michael.hottiger@dmmd.uzh.ch.

PMID: 27693398
DOI: 10.1016/j.semcdb.2016.09.010

Abstract

ADP-ribosylation is an evolutionarily conserved complex posttranslational modification that alters protein function and/or interaction. Intracellularly, it is mainly catalyzed by diphtheria toxin-like ADP-ribosyltransferases (ARTDs), which attach one or several ADP-ribose residues onto target proteins. Several specific mono- and poly-ADP-ribosylation binding modules exist; hydrolases reverse the modification. The best-characterized ARTD family member, ARTD1, regulates various DNA-associated processes. Here, we focus on the role of ARTD1-mediated chromatin ADP-ribosylation in development, differentiation, and pluripotency, and the recent development of new methodologies that will enable more insight into these processes.

Keywords: ADP-ribosylation; ARTD; Chromatin; Differentiation; Histone; PARP; Pluripotency.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

ADP-Ribosylation*
Animals
Cell Differentiation / genetics
Cell Lineage* / genetics
Chromatin / metabolism*
Epigenesis, Genetic
Humans
Protein Processing, Post-Translational / genetics

Substances

Chromatin