Does intensity or youth affect the neurobiological effect of exercise on major depressive disorder?

Henning Budde; Bruna Velasques; Pedro Ribeiro; Sergio Machado; Arunas Emeljanovas; Sigitas Kamandulis; Albertas Skurvydas; Mirko Wegner

doi:10.1016/j.neubiorev.2016.09.026

Does intensity or youth affect the neurobiological effect of exercise on major depressive disorder?

Neurosci Biobehav Rev. 2018 Jan:84:492-494. doi: 10.1016/j.neubiorev.2016.09.026. Epub 2016 Sep 28.

Authors

Henning Budde¹, Bruna Velasques², Pedro Ribeiro², Sergio Machado³, Arunas Emeljanovas⁴, Sigitas Kamandulis⁴, Albertas Skurvydas⁴, Mirko Wegner⁵

Affiliations

¹ Faculty of Human Sciences, Medical School Hamburg, Hamburg, Germany; Physical Activity, Physical Education, Health and Sport Research Centre (PAPESH), Sports Science Department, School of Science and Engineering, Reykjavik University, Reykjavik, Iceland; Lithuanian Sports University, Kaunas, Lithuania. Electronic address: henningb@ru.is.
² Bioscience Department, School of Physical Education of the Federal University of Rio de Janeiro (EEFD/UFRJ), Rio de Janeiro, Brazil; Institute of Applied Neuroscience (INA), Rio de Janeiro, Brazil.
³ Panic and Respiration Lab, Institute of Psichiatry, Federal University of Rio de Janeiro (IPUB/UFRJ), Rio de Janeiro, Brazil; Physical Activity Neuroscience, Physical Activity Sciences Postgraduate Program, Salgado de Oliveira University, Niterói, Brazil.
⁴ Lithuanian Sports University, Kaunas, Lithuania.
⁵ Institute of Sport Science, University of Bern, Switzerland.

PMID: 27693226
DOI: 10.1016/j.neubiorev.2016.09.026

Abstract

The purpose of this commentary is to discuss the different neurobiological effects of exercise on major depressive disorder (MDD) in children and adolescents and to provide additional explanations to this well written systematic review. This commentary highlights the effects of exercise on the hypothalamic-pituitary-adrenal (HPA) axis, which plays a crucial role in MDD. We address the questions of whether age and different exercise intensities may provide additional information on the neurobiological effects of acute or chronic exercise on MDD. Previous findings clearly suggest that the etiology of MDD is complex and multifaceted, involving numerous neurobiological systems, which are additionally influenced by these two factors.

Keywords: Age; Cortisol; Depression; Exercise; Exercise intensity; HPA-axis.

Publication types

Comment

MeSH terms

Adolescent
Child
Depressive Disorder, Major*
Humans
Hydrocortisone
Hypothalamo-Hypophyseal System
Neurobiology
Pituitary-Adrenal System

Substances

Hydrocortisone