Fortifying p53 - beyond Mdm2 inhibitors

Aging (Albany NY). 2016 Sep 29;8(9):1836-1837. doi: 10.18632/aging.101073.
No abstract available

Keywords: Mdm2; PPM1D; Wip1; cancer treatment; p53.

MeSH terms

  • Animals
  • Antineoplastic Agents / therapeutic use*
  • Enzyme Inhibitors / therapeutic use*
  • Humans
  • Neoplasms / drug therapy*
  • Neoplasms / enzymology
  • Neoplasms / genetics
  • Neoplasms / pathology
  • Protein Phosphatase 2C / genetics
  • Protein Phosphatase 2C / metabolism
  • Proto-Oncogene Proteins c-mdm2 / antagonists & inhibitors*
  • Proto-Oncogene Proteins c-mdm2 / genetics
  • Proto-Oncogene Proteins c-mdm2 / metabolism
  • Signal Transduction / drug effects
  • Tumor Suppressor Protein p53 / genetics
  • Tumor Suppressor Protein p53 / metabolism*

Substances

  • Antineoplastic Agents
  • Enzyme Inhibitors
  • TP53 protein, human
  • Tumor Suppressor Protein p53
  • MDM2 protein, human
  • Proto-Oncogene Proteins c-mdm2
  • PPM1D protein, human
  • Protein Phosphatase 2C