A new C20-diterpenoid alkaloid from the lateral roots of Aconitum carmichaeli

Nat Prod Res. 2017 Jan;31(2):228-232. doi: 10.1080/14786419.2016.1219863. Epub 2016 Aug 11.

Abstract

A new C20-diterpenoid alkaloid carmichaedine (1) and six known alkaloids (2-7) were isolated from the lateral roots of Aconitum carmichaeli. Their structures were established on the basis of extensive spectroscopic analyses. Compound 1 exhibited potent antibacterial activity against Bacillus subtilis with minimum inhibitory concentration of 8 μg/mL.

Keywords: Aconitum carmichaeli; Ranunculaceae; antibacterial; carmichaedine; diterpenoid alkaloid.

MeSH terms

  • Aconitum / chemistry*
  • Alkaloids / analysis
  • Alkaloids / chemistry
  • Alkaloids / isolation & purification*
  • Anti-Bacterial Agents / analysis
  • Anti-Bacterial Agents / isolation & purification
  • Bacillus subtilis / drug effects
  • Diterpenes / analysis
  • Diterpenes / chemistry
  • Diterpenes / isolation & purification*
  • Microbial Sensitivity Tests
  • Molecular Structure
  • Plant Roots / chemistry*
  • Spectrum Analysis

Substances

  • Alkaloids
  • Anti-Bacterial Agents
  • Diterpenes