Curacin E from the Brittle Star Ophiocoma scolopendrina

Reiko Ueoka; Yuki Hitora; Akihiro Ito; Minoru Yoshida; Shigeru Okada; Kentaro Takada; Shigeki Matsunaga

doi:10.1021/acs.jnatprod.6b00701

Curacin E from the Brittle Star Ophiocoma scolopendrina

J Nat Prod. 2016 Oct 28;79(10):2754-2757. doi: 10.1021/acs.jnatprod.6b00701. Epub 2016 Sep 29.

Authors

Reiko Ueoka¹, Yuki Hitora¹, Akihiro Ito^{2

3}, Minoru Yoshida^{2

3}, Shigeru Okada¹, Kentaro Takada¹, Shigeki Matsunaga¹

Affiliations

¹ Laboratory of Aquatic Natural Products Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo , Bunkyo-ku, Tokyo 113-8657, Japan.
² Chemical Genomics Reserach Group, RIKEN Center for Sustainable Resource Science , Wako Saitama 351-0198, Japan.
³ Chemical Genetics Laboratory, RIKEN , Wako Saitama 351-0198, Japan.

PMID: 27684202
DOI: 10.1021/acs.jnatprod.6b00701

Abstract

Bioassay-guided fractionation of the extract of the brittle star Ophiocoma scolopendrina afforded curacin E (1), a congener of curacin A (2). Curacin A (2) is an antimitotic agent of cyanobacterial origin. The structure of curacin E was studied by interpretation of NMR data and the ECD spectrum. Curacin E has an ethylcarbonyl terminus in its side chain and inhibits the proliferation of P388 cells.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antineoplastic Agents / pharmacology
Cyanobacteria / chemistry
Cyclopropanes / chemistry
Cyclopropanes / isolation & purification*
Echinodermata / chemistry*
Mitosis / drug effects
Molecular Structure
Thiazoles / chemistry
Thiazoles / isolation & purification*
Tubulin / metabolism

Substances

Antineoplastic Agents
Cyclopropanes
Thiazoles
Tubulin
curacin E
curacin A