Recent advances in enhancing the sensitivity of electrophoresis and electrochromatography in capillaries and microchips (2014-2016)

Electrophoresis. 2017 Jan;38(1):33-59. doi: 10.1002/elps.201600331. Epub 2016 Nov 17.

Abstract

One of the most cited limitations of capillary (and microchip) electrophoresis is the poor sensitivity. This review continues to update this series of biennial reviews, first published in Electrophoresis in 2007, on developments in the field of on-line/in-line concentration methods in capillaries and microchips, covering the period July 2014-June 2016. It includes developments in the field of stacking, covering all methods from field amplified sample stacking and large volume sample stacking, through to isotachophoresis, dynamic pH junction, and sweeping. Attention is also given to on-line or in-line extraction methods that have been used for electrophoresis.

Keywords: Extraction; Focusing; Preconcentration; Stacking; Sweeping.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Capillary Electrochromatography
  • Cell Line
  • Electrophoresis, Capillary / methods*
  • Humans
  • Inorganic Chemicals / analysis
  • Isoelectric Focusing
  • Isotachophoresis / methods*
  • Microchip Analytical Procedures / methods*
  • Nanostructures / analysis
  • Organic Chemicals / analysis
  • Sensitivity and Specificity

Substances

  • Inorganic Chemicals
  • Organic Chemicals