The Actin Cortex: A Bridge between Cell Shape and Function

Kevin J Chalut; Ewa K Paluch

doi:10.1016/j.devcel.2016.09.011

The Actin Cortex: A Bridge between Cell Shape and Function

Dev Cell. 2016 Sep 26;38(6):571-3. doi: 10.1016/j.devcel.2016.09.011.

Authors

Kevin J Chalut¹, Ewa K Paluch²

Affiliations

¹ Wellcome Trust/Medical Research Council Stem Cell Institute, University of Cambridge CB2 1QR, Cambridge, UK. Electronic address: kc370@cam.ac.uk.
² MRC-LMCB, University College London WC1E 6BT, London, UK; Institute for the Physics of Living Systems, University College London WC1E 6BT, London, UK. Electronic address: e.paluch@ucl.ac.uk.

PMID: 27676427
DOI: 10.1016/j.devcel.2016.09.011

Abstract

The cortical actin network controls many animal cell shape changes by locally modulating cortical tension. Recent work has provided insight into cortex components and regulators. However, how the network is reorganized in response to cellular signaling, and the role reorganization may play during cell state changes, remain to be determined.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Actin Cytoskeleton / genetics*
Actin Cytoskeleton / metabolism
Actins / genetics*
Actins / metabolism
Animals
Cell Shape / genetics
Humans
Morphogenesis / genetics*
Signal Transduction

Substances

Actins

Abstract

Publication types

MeSH terms

Substances

Grants and funding