Impaired Spatial Learning is Associated with Disrupted Integrity of the White Matter in Akt3 Knockout Mice

CNS Neurosci Ther. 2017 Jan;23(1):99-102. doi: 10.1111/cns.12647. Epub 2016 Sep 27.

Authors

He Wang¹, Bao-Feng Zhang², Ting-Ting Zhang², Long Wang¹, Xiao-Yan Zou¹, Yun Xu³, Ling Chen², Gui-Quan Chen¹

Affiliations

¹ State Key Laboratory of Pharmaceutical Biotechnology, MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center, Nanjing University, Nanjing, Jiangsu Province, China.
² Department of Physiology, Nanjing Medical University, Nanjing, China.
³ Department of Neurology, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, Jiangsu Province, China.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Immunohistochemistry
Mice, Knockout
Myelin Basic Protein / metabolism
Proto-Oncogene Proteins c-akt / deficiency*
Proto-Oncogene Proteins c-akt / genetics
Spatial Learning / physiology*
Spatial Memory / physiology
White Matter / metabolism*
White Matter / pathology*

Substances

Mbp protein, mouse
Myelin Basic Protein
Akt1 protein, mouse
Akt3 protein, mouse
Proto-Oncogene Proteins c-akt