Abstract
In vitro activities of omadacycline, a new aminomethylcycline, were determined for Mycoplasma and Ureaplasma spp. and compared with those of azithromycin, clindamycin, moxifloxacin, tetracycline, and doxycycline. All omadacycline MICs were <2 μg/ml. MIC90s were 0.063 μg/ml for Mycoplasma hominis, 0.25 μg/ml for Mycoplasma pneumoniae, and 2 μg/ml for Ureaplasma spp. Omadacycline had the lowest MIC90 among all drugs tested against M. hominis Omadacycline activity was not affected by macrolide, tetracycline, or fluoroquinolone resistance.
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MeSH terms
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Anti-Bacterial Agents / pharmacology*
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Azithromycin / pharmacology
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China
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Clindamycin / pharmacology
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Doxycycline / pharmacology
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Drug Resistance, Multiple, Bacterial
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Fluoroquinolones / pharmacology
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Humans
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Microbial Sensitivity Tests
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Moxifloxacin
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Mycoplasma Infections / microbiology
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Mycoplasma hominis / drug effects*
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Mycoplasma hominis / growth & development
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Mycoplasma hominis / isolation & purification
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Mycoplasma pneumoniae / drug effects*
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Mycoplasma pneumoniae / growth & development
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Mycoplasma pneumoniae / isolation & purification
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Tetracycline / pharmacology
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Tetracyclines / pharmacology*
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United States
Substances
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Anti-Bacterial Agents
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Fluoroquinolones
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Tetracyclines
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omadacycline
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Clindamycin
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Azithromycin
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Tetracycline
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Doxycycline
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Moxifloxacin