Analysis of LRRK2, SNCA, and ITGA8 Gene Variants with Sporadic Parkinson's Disease Susceptibility in Chinese Han Population

Jie Fang; Kehui Yi; Mingwei Guo; Xingkai An; Hongli Qu; Qing Lin; Min Bi; Qilin Ma

doi:10.1155/2016/3474751

Analysis of LRRK2, SNCA, and ITGA8 Gene Variants with Sporadic Parkinson's Disease Susceptibility in Chinese Han Population

Parkinsons Dis. 2016:2016:3474751. doi: 10.1155/2016/3474751. Epub 2016 Sep 7.

Authors

Jie Fang¹, Kehui Yi², Mingwei Guo³, Xingkai An¹, Hongli Qu¹, Qing Lin¹, Min Bi¹, Qilin Ma⁴

Affiliations

¹ Department of Neurology, The First Affiliated Hospital of Xiamen University, Xiamen, China.
² The First Clinical Medical College of Fujian Medical University, Fuzhou, China.
³ Department of Neurology, The First Affiliated Hospital of Gannan Medical University, Ganzhou, China.
⁴ Department of Neurology, The First Affiliated Hospital of Xiamen University, Xiamen, China; The First Clinical Medical College of Fujian Medical University, Fuzhou, China.

Abstract

Background. Parkinson's disease (PD) is an age-related neurodegenerative disease affected by multiple genetic and environmental factors. We performed a case-control study on candidate gene to scrutinize whether genetic variants in LRRK2, SNCA, and ITGA8 genes could be associated with sporadic PD in Chinese Han population. Methods. Five single-nucleotide polymorphisms (SNPs) of LRRK2 (rs1491942), SNCA (rs2301134, rs2301135, and rs356221), and ITGA8 (rs7077361) were selected and genotyped among 583 unrelated PD patients and 558 healthy controls. Results. Rs1491942 of LRRK2 gene had a significantly higher genotype frequency (P = 3.543E - 09) and allelic G/C frequencies (P = 2.601E - 10) in PD patients than controls. Rs2301135 of SNCA gene also showed an obvious difference in genotype frequency (P = 4.394E - 07) and allelic G/C frequencies (P = 9.116E - 13) between PD patients and controls. SNPs rs2301134 and rs356221 of SNCA gene and rs7077361 of ITGA8 gene lacked the significant association with the susceptibility of PD in Chinese Han population. Conclusions. Our study firstly expresses that rs1491942 of LRRK2 and rs2301135 of SNCA gene are substantially associated with sporadic Parkinson's disease in Chinese Han population.