Two new limonoids isolated from the fuits of Melia toosendan

Chin J Nat Med. 2016 Sep;14(9):692-696. doi: 10.1016/S1875-5364(16)30082-6.

Abstract

In the present study, two new limonoids, 1α, 7α-dihydroxyl-3α-acetoxyl-12α-ethoxylnimbolinin (1) and 1α-tigloyloxy-3α-acetoxyl-7α-hydroxyl-12β-ethoxylnimbolinin (2), together with other four known limonoids (3-6), were isolated from the fruits of Melia toosendan. Their structures were elucidated by means of extensive spectroscopic analyses (NMR and ESI-MS) and comparisons with the data reported in the literature. The isolated compounds were evaluated for their antibacterial activities. Compound 4 exhibited significant antibacterial activity against an oral pathogen, Porphyromonas gingivalis ATCC 33277, with an MIC value of 15.2 μg·mL(-1). Compound 2 was also active against P. gingivalis ATCC 33277, with an MIC value of 31.25 μg·mL(-1). In conlcusion, our resutls indicate that these compounds may provide a basis for future development of novel antibiotics.

Keywords: Antibacterial; Limonoid; Melia toosendan; Meliaceae; Oral pathogen.

MeSH terms

  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / isolation & purification*
  • Anti-Bacterial Agents / pharmacology
  • Drugs, Chinese Herbal / chemistry
  • Drugs, Chinese Herbal / isolation & purification*
  • Fruit / chemistry
  • Limonins / chemistry
  • Limonins / isolation & purification*
  • Magnetic Resonance Spectroscopy
  • Melia / chemistry*
  • Molecular Structure
  • Porphyromonas gingivalis / drug effects
  • Porphyromonas gingivalis / growth & development
  • Spectrometry, Mass, Electrospray Ionization

Substances

  • Anti-Bacterial Agents
  • Drugs, Chinese Herbal
  • Limonins