Appearance of a transient inv(14)(q11q32) in a case of B cell chronic lymphocytic leukemia

B Schlegelberger; L Zech; H Euler; H Löffler; A Himmler; A Feller

doi:10.1016/0165-4608(89)90111-8

Appearance of a transient inv(14)(q11q32) in a case of B cell chronic lymphocytic leukemia

Cancer Genet Cytogenet. 1989 Aug;41(1):87-92. doi: 10.1016/0165-4608(89)90111-8.

Authors

B Schlegelberger¹, L Zech, H Euler, H Löffler, A Himmler, A Feller

Affiliation

¹ Department of Human Genetics, Christian Albrechts-Universität, Kiel, West Germany.

PMID: 2766254
DOI: 10.1016/0165-4608(89)90111-8

Abstract

The inv(14)(q11q32) has been reported to be a specific chromosome aberration in T-cell chronic lymphocytic leukemia (T-CLL) and different types of T-cell lymphomas. Here, the first case of B-CLL with a clonal inv(14)(q11q32) in a phytohemagglutinin-stimulated bone marrow culture is presented. In a subsequent study 9 months later, tetradecanoyl-o-phorbol-13-acetate stimulated blood and bone marrow cultures revealed a clone with a t(1;11)(p13.2;q23.1) and an aberrant chromosome 17.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Aged
Chromosome Banding
Chromosome Inversion*
Chromosomes, Human, Pair 14*
Humans
Karyotyping
Leukemia, Lymphocytic, Chronic, B-Cell / genetics*
Male